Pope-Vannoy Landing is located at the east end of Iliamna Lake, northeast of Kokhanok, off of Intricate Bay. It lies about 175 air miles southwest of Anchorage on the Alaska Peninsula.
The lake experiences a transitional climatic zone with strong maritime influences. Average summer temperatures range from 42 to 62 °F; winter temperatures range from 6 to 30 °F. Annual rainfall averages 26 inches, with 64 inches of snowfall.
Chartered float planes provide air services from Anchorage, Iliamna, and King Salmon. Supplies delivered by barge via the Kvichak River must be lightered to shore. Skiffs, ATVs, and trucks are common forms of local transportation.